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HepaticA 62-year-old man with erosive esophagitis developed signs and symptoms of hepatic disease 17 days after the start of therapy with omeprazole 20 mg per day. 2 Clinical Trials Experience with Omeprazole Delayed-release Capsules USP in Combination Therapy for H. He was administered a single dose of omeprazole 40 mg. Animal studies have demonstrated an increase in plasma gastrin concentrations following the administration of omeprazole. Fatal fulminant hepatic failure attributed to omeprazole has also been reported.

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